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„Association of Coffee and Caffeine Intake With the Risk of Parkinson Disease Ross et al. JAMA.2000; 283: 2674-2679.“
http://jama.ama-assn.org/cgi/reprint/283/20/ 2674 - Cached
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„Age-adjusted incidence of PD declined consistently with increased amounts of coffee intake, from 10.4 per 10,000 person-years in men who drank no coffee to 1.9 per 10,000 person-years in men who drank at least 28 oz/d (P“
http://jama.ama-assn.org/cgi/content/abstract/283/20/ 2674
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„INTERVENTIONS--Subjects underwent a 4-week habituation period to become familiar with the RPE scale and exercise on an Airdyne, a cross-country skiing simulator, a cycle ergometer, a rowing ergometer, a stair stepper, and a treadmill. Following habituation, each subject completed an exercise test with each exercise machine. The exercise test comprised 3 stages of 5 minutes at self-selected work rates corresponding to RPE values of 11 (fairly light), 13 (somewhat hard), and 15 (hard). Oxygen consumption, from which the rate of energy expenditure was calculated, was measured during the last minute of each 5-minute exercise stage.“
http://jama.ama-assn.org/cgi/content/abstract/275/18/ 1424
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„Criteria used for making diagnoses (and rates of their prevalence) were as follows: withdrawal (94%), use continued despite knowledge of a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by caffeine use (94%), persistent desire or unsuccessful efforts to cut down or control use (81%), and tolerance (75%). Eleven subjects underwent the double-blind caffeine-withdrawal evaluation portion of the study, and nine (82%) of the 11 showed objective evidence of caffeine withdrawal, including eight of 11 with functional impairment. CONCLUSIONS--These results, together with other experimental evidence, suggest that caffeine exhibits the features of a typical psychoactive substance of dependence. It is valuable to recognize caffeine dependence as a clinical syndrome, since some people feel compelled to continue caffeine use despite desires and recommendations to the contrary.“
http://jama.ama-assn.org/cgi/content/abstract/272/13/ 1043
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„Little information is known regarding caffeine's effect on the substrate supporting sustained ventricular arrhythmias. This prospective study evaluated the effect of coffee (275 mg of caffeine) on this substrate with programmed ventricular stimulation in 22 patients with a history of symptomatic nonsustained ventricular tachycardia, ventricular tachycardia, or ventricular fibrillation. Patients underwent electrophysiological testing before and 1 hour after coffee ingestion. Mean (+/- SEM) plasma caffeine level achieved after coffee consumption was 6.2 +/- 0.5 mg/L.“
http://jama.ama-assn.org/cgi/content/abstract/264/17/ 2236
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