JAMA -- Easy on the Antioxidants, May 17, 2000, Stephenson 283 (19): 2514 (#)
„Interest in antioxidants such as vitamins C and E, selenium, and carotenoids has soared in recent years, in large part due to epidemiological studies suggesting that foods rich in these substances reduce the risk of chronic diseases. But a new report from the Institute of Medicine warns that people who ingest these substances in the form of dietary supplements should be aware that benefits are unproven and large doses can harm rather than help.“
http://jama.ama-assn.org/cgi/content/extract/283/19/ 2514 - Cached
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„Criteria used for making diagnoses (and rates of their prevalence) were as follows: withdrawal (94%), use continued despite knowledge of a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by caffeine use (94%), persistent desire or unsuccessful efforts to cut down or control use (81%), and tolerance (75%). Eleven subjects underwent the double-blind caffeine-withdrawal evaluation portion of the study, and nine (82%) of the 11 showed objective evidence of caffeine withdrawal, including eight of 11 with functional impairment. CONCLUSIONS--These results, together with other experimental evidence, suggest that caffeine exhibits the features of a typical psychoactive substance of dependence. It is valuable to recognize caffeine dependence as a clinical syndrome, since some people feel compelled to continue caffeine use despite desires and recommendations to the contrary.“
http://jama.ama-assn.org/cgi/content/abstract/272/13/ 1043
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„Age-adjusted incidence of PD declined consistently with increased amounts of coffee intake, from 10.4 per 10,000 person-years in men who drank no coffee to 1.9 per 10,000 person-years in men who drank at least 28 oz/d (P“
http://jama.ama-assn.org/cgi/content/abstract/283/20/ 2674
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„Strategies to Decrease Tuberculosis in US Homeless Populations: A Computer Simulation... Brewer et al. JAMA.2001; 286: 834-842.“
http://jama.ama-assn.org/cgi/content/full/286/7/ 834
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„Little information is known regarding caffeine's effect on the substrate supporting sustained ventricular arrhythmias. This prospective study evaluated the effect of coffee (275 mg of caffeine) on this substrate with programmed ventricular stimulation in 22 patients with a history of symptomatic nonsustained ventricular tachycardia, ventricular tachycardia, or ventricular fibrillation. Patients underwent electrophysiological testing before and 1 hour after coffee ingestion. Mean (+/- SEM) plasma caffeine level achieved after coffee consumption was 6.2 +/- 0.5 mg/L.“
http://jama.ama-assn.org/cgi/content/abstract/264/17/ 2236
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JAMA -- Table of Contents (Vol. 269 No. 13, April 7, 1993)
„Treating cancer with coffee enemas and diet B. Brown JAMA. 1993;269:1635-1636.“
http://jama.ama-assn.org/content/vol269/issue13/ index.dtl
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