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JAMA -- Cranberry Juice and Adhesion of Antibiotic-Resistant Uropathogens, June 19, 2002, Howell and Foxman 287 (23): 3082

JAMA -- Cranberry Juice and Adhesion of Antibiotic-Resistant Uropathogens, June 19, 2002, Howell and Foxman 287 (23): 3082 ()

  „To the Editor: Urinary tract infections (UTIs) account for more than 11 million physician visits annually in the United States and have become increasingly resistant to first-line antibiotic therapy.1 Recent evidence suggests that consumption of cranberry juice beverages is effective at preventing UTIs,2-3 although further studies are needed to validate potential treatment effects. While early research focused on a mechanism of urinary acidification, the largest clinical trial to date found no evidence to support this.2 Recent studies suggest that cranberry proanthocyanidins (condensed tannins) may inhibit P-fimbriated Escherichia coli from adhering to uroepithelial cells,4 the initial step in development of UTI. The effectiveness of cranberry proanthocyanidins and cranberry beverages against antibiotic-resistant E coli, however, has not been previously tested. We assessed whether consumption of cranberry juice cocktail prevents adhesion of antibiotic-resistant uropathogenic P-fimbriated E coli to the uroepithelium.“

http://jama.ama-assn.org/cgi/content/extract/287/23/ 3082 - Cached

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